[HTML][HTML] Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1α containing Pro564
Under normoxic conditions the alpha-subunit of hypoxia-inducible factor (HIF-1α) protein is
targeted for degradation by the von Hippel-Lindau (VHL) tumor suppressor protein acting as
an E3 ubiquitin ligase. Recently, we developed a hypoxia-targeting protein, TOP3, which
consisted of procaspase-3 with the VHL-mediated protein destruction motif of HIF-1α. This
design enables procaspase-3 to be regulated similarly with HIF-1α, being degraded under
normoxia while stabilized under hypoxia. Furthermore, stabilized TOP3 was cleaved by the …
targeted for degradation by the von Hippel-Lindau (VHL) tumor suppressor protein acting as
an E3 ubiquitin ligase. Recently, we developed a hypoxia-targeting protein, TOP3, which
consisted of procaspase-3 with the VHL-mediated protein destruction motif of HIF-1α. This
design enables procaspase-3 to be regulated similarly with HIF-1α, being degraded under
normoxia while stabilized under hypoxia. Furthermore, stabilized TOP3 was cleaved by the …
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